Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitizationd

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Imamura M., Ezquerro F., Alfieri F., Boas L. V., Tozetto-Mendoza T. R., Chen J., ...More

INTERNATIONAL JOURNAL OF INFLAMMATION, vol.2015, 2015 (ESCI) identifier identifier


Osteoarthritis (OA) is themost common joint disorder in the world. Among themechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-alpha) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.