Recent advances in liposome-based targeted cancer therapy

Fidan Y., Muçaj S., TİMUR S. S., GÜRSOY R. N.

Journal of Liposome Research, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/08982104.2023.2268710
  • Dergi Adı: Journal of Liposome Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, MEDLINE
  • Anahtar Kelimeler: active targeting, cancer, drug delivery system, Liposome, passive targeting
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Nano-drug delivery systems have opened new pathways for tumor treatment by overcoming some of the limitations of conventional drugs, such as physiological degradation, short half-life, and rapid release. Liposomes are promising nanocarrier systems due to their biocompatibility, low toxicity, and high inclusivity, as well as their enhanced drug bioavailability. Various strategies for active targeting of liposomal formulations have been investigated to achieve the highest drug efficacy. This review aims to summarize current developments in novel liposomal formulations, particularly ligand-targeted liposomes (such as folate, transferrin, hyaluronic acid, antibodies, aptamer, and peptide, etc.) used for the therapy of various cancers and provide an insight on the challenges and future of liposomes for scientists and pharmaceutical companies.