Clinicopathologic and radiopharmacokinetic factors affecting gamma probe-guided parathyroidectomy.

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Ugur O., Bozkurt M. F., Hamaloglu E., Sokmensuer C., Etikan I., Ugur Y., ...More

Archives of surgery (Chicago, Ill. : 1960), vol.139, no.11, pp.1175-9, 2004 (SCI-Expanded) identifier identifier identifier


Hypothesis: The kinetics of technetium Tc 99m sestamibi (MIBI) in primary hyperparathyroidism are variable and affected by the cellular size of the abnormal glands, the parathyroid hormone levels, and the functional expression of P-glycoprotein (Pgp). The success of gamma probe-guided parathyroidectomy is closely related to the parathyroid-to-thyroid activity ratio at the time of surgery. Preoperative determination of maximum uptake ratio may improve the surgical outcome.