Clinicopathologic and radiopharmacokinetic factors affecting gamma probe-guided parathyroidectomy.

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Ugur O. , Bozkurt M. F. , Hamaloglu E. , Sokmensuer C., Etikan I. , Ugur Y., ...Daha Fazla

Archives of surgery (Chicago, Ill. : 1960), cilt.139, sa.11, ss.1175-9, 2004 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 139 Konu: 11
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1001/archsurg.139.11.1175
  • Dergi Adı: Archives of surgery (Chicago, Ill. : 1960)
  • Sayfa Sayıları: ss.1175-9


Hypothesis: The kinetics of technetium Tc 99m sestamibi (MIBI) in primary hyperparathyroidism are variable and affected by the cellular size of the abnormal glands, the parathyroid hormone levels, and the functional expression of P-glycoprotein (Pgp). The success of gamma probe-guided parathyroidectomy is closely related to the parathyroid-to-thyroid activity ratio at the time of surgery. Preoperative determination of maximum uptake ratio may improve the surgical outcome.