Chemotherapy as a salvage strategy after immunotherapy failure in advanced hepatocellular carcinoma: A case series
Clinics and Research in Hepatology and Gastroenterology, cilt.50, sa.6, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Kısa Makale
- Cilt numarası: 50 Sayı: 6
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.clinre.2026.102831
- Dergi Adı: Clinics and Research in Hepatology and Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
- Hacettepe Üniversitesi Adresli: Evet
Özet
The role of systemic chemotherapy after immunotherapy failure in advanced hepatocellular carcinoma (HCC) remains poorly defined. We describe five patients with advanced HCC who progressed on immune checkpoint inhibitor–based therapy and subsequently received cytotoxic chemotherapy. Gemcitabine-, fluorouracil-, and platinum-based chemotherapy regimens, including hepatic arterial infusion chemotherapy in one patient, were administered. Three patients achieved a partial radiologic response, whereas two showed early disease progression. These descriptive observations suggest that, in carefully selected patients with preserved liver function and good performance status, chemotherapy may be associated with radiologic disease control after immunotherapy failure.