Because the preparation of standard samples may not always be possible for weak or soft rocks, the prediction of uniaxial compressive strength (UCS) from indirect methods is widely used for preliminary investigations. In this study, the possibility of predicting UCS from the slake durability index (SDI) was investigated for pyroclastic rocks. For this purpose, pyroclastic rocks were collected from 31 different locations in the Cappadocian Volcanic Province of Turkey. The UCS and SDI tests were carried out on the samples in the laboratory. The UCS values were correlated with the SDI values and a very strong exponential relation was found between the two parameters. Since some data were scattered over the UCS values of 20 MPa, the correlation plot was redrawn for above and below the UCS values of 20 MPa, respectively. Very strong linear correlations were developed for two cases. Our concluding remark is that the UCS of pyroclastic rocks can be estimated from the SDI.