McCune-Albright syndrome associated with acromegaly and bipolar affective disorder

OZCAN-KARA P., MAHMOUDIAN B., Erbas B., ERBAS T.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, cilt.18, sa.8, ss.600-602, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.ejim.2007.02.030
  • Dergi Adı: EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.600-602
  • Hacettepe Üniversitesi Adresli: Evet

Özet

McCune - Albright syndrome is a rare disorder caused by an activating mutation in the gene (GNAS1) encoding the subunit of the G protein. This syndrome is characterized by polyostotic fibrous dysplasia, cafe-au-lait pigmentation, and multiple endocrine hyperfunction. A 29-year-old male with polyostotic fibrous dysplasia, cafe-au-lait pigmentations, and pituitary adenoma is presented in this report. The patient had accompanying bipolar affective disorder; which might have been caused by the underlying genetic abnormality. (c) 2007 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.