McCune-Albright syndrome associated with acromegaly and bipolar affective disorder


OZCAN-KARA P. , MAHMOUDIAN B., Erbas B., ERBAS T.

EUROPEAN JOURNAL OF INTERNAL MEDICINE, cilt.18, ss.600-602, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 8
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.ejim.2007.02.030
  • Dergi Adı: EUROPEAN JOURNAL OF INTERNAL MEDICINE
  • Sayfa Sayıları: ss.600-602

Özet

McCune - Albright syndrome is a rare disorder caused by an activating mutation in the gene (GNAS1) encoding the subunit of the G protein. This syndrome is characterized by polyostotic fibrous dysplasia, cafe-au-lait pigmentation, and multiple endocrine hyperfunction. A 29-year-old male with polyostotic fibrous dysplasia, cafe-au-lait pigmentations, and pituitary adenoma is presented in this report. The patient had accompanying bipolar affective disorder; which might have been caused by the underlying genetic abnormality. (c) 2007 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.