Structural and stereochemical analysis of some 9-phenyl-8-N-substituted thiocarbamoyl-7,8-diazabicyclo[4.3.0]non-6-enes by NMR and mass spectrometric techniques
SPECTROSCOPY LETTERS, cilt.29, sa.8, ss.1481-1496, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 8
- Basım Tarihi: 1996
- Doi Numarası: 10.1080/00387019608007139
- Dergi Adı: SPECTROSCOPY LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1481-1496
- Hacettepe Üniversitesi Adresli: Evet
Özet
In this study the structural and stereochemical analysis of some 9-Phenyl-8-N-Substituted thiocarbamoyl-7,8-diazabicyclo[4.-3.0] and the new synthesized 5-Methyl-9-phenyl-8-N-Substituted-thiocarbamoyl-7,8-diazabicyclo[4.-3.0]non-6-enes derivatives were studied by 2D NMR, 1D NOE experiments and electron impact mass spectrometry were reported. The N-substituted thiocarbamoyl compounds were mixtures of diastereomers as evidenced by differing Rf values on TLC plates. They were separated by successive applications of preparative TLC and structures were elucidated by IR, H-1-NMR, C-13-NMR, DEPT, 2D-NMR and EI-MASS techniques. The cis-trans isomerism of the compounds were determined by means of H-1-NMR C-13-NMR and 1D NOE difference experiments. The conformation analysis of the bicyclic ring system was based on NOE difference experiments and NOESY spectra of compound-11. For the application of 1D NOE experiments, compound 11 was selected.