Serum alpha-fetoprotein levels in neonatal cholestasis

DEMİR H., Hizal G., USLU KIZILKAN N., Gurakan F., TALİM B., COŞKUN T., ...Daha Fazla

TURKISH JOURNAL OF PEDIATRICS, cilt.55, sa.2, ss.152-157, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.152-157
  • Anahtar Kelimeler: neonatal cholestasis, alpha-fetoprotein elevation, steatosis, aspartate aminotransferase elevation, CHRONIC HEPATITIS-C, FATTY LIVER-DISEASE, MITOCHONDRIAL DYSFUNCTION, HEPATOCELLULAR-CARCINOMA, CLINICAL-SIGNIFICANCE, CITRIN DEFICIENCY, VIRAL-HEPATITIS, BILIARY ATRESIA, VIRUS-INFECTION, INFANTS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Alpha-fetoprotein (AFP) is used as a tumor marker for hepatocellular carcinoma, hepatoblastoma and germ cell tumors. It may also be elevated in infants with some hepatobiliary disorders. The mechanism of AFP elevation in neonatal cholestasis is not known. We retrospectively evaluated serum AFP levels in 53 infants with neonatal cholestasis. Thirty patients (56.6%) had elevated AFP, and the ratio of patients with elevated AFP was significantly high in both the metabolic diseases and idiopathic neonatal hepatitis groups (p=0.021). Serum aspartate aminotransferase (AST) levels increased significantly in patients with elevated AFP (p=0.004). Steatosis was the distinctive histopathological finding of the patients with high AFP. The patients with steatosis had significantly higher standard deviation (SD) score of AFP than the patients without steatosis (p=0.001). We have shown AFP elevation in neonatal cholestasis due to metabolic disorders and idiopathic neonatal hepatitis and its association with steatosis and AST elevation.