Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke

Traylor, Matthew; Malik, Rainer; Nalls, Mike; Cotlarciuc, Ioana; Radmanesh, Farid; Thorleifsson, Gudmar; Hanscombe, Ken; Langefeld, Carl; Saleheen, Danish; Rost, Natalia; Yet, İDİL; Spector, Tim; Bell, Jordana; Hannon, Eilis; Mill, Jonathan; Chauhan, Ganesh; Debette, Stephanie; Bis, Joshua; Longstreth, W.; Ikram, M.; Launer, Lenore; Seshadri, Sudha; Hamilton-Bruce, Monica; Jimenez-Conde, Jordi; Cole, John; Schmidt, Reinhold; Slowik, Agnieszka; Lemmens, Robin; Lindgren, Arne; Melander, Olle; Grewal, Raji; Sacco, Ralph; Rundek, Tatjana; Rexrode, Kathryn; Arnett, Donna; Johnson, Julie; Benavente, Oscar; Wasssertheil-Smoller, Sylvia; Lee, Jin-Moo; Pulit, Sara; Wong, Quenna; Rich, Stephen; de Bakker, Paul; McArdle, Patrick; Woo, Daniel; Anderson, Christopher; Xu, Huichun; Heitsch, Laura; Fornage, Myriam; Jern, Christina; Stefansson, Kari; Thorsteinsdottir, Unnur; Gretarsdottir, Solveig; Lewis, Cathryn; Sharma, Pankaj; Sudlow, Cathie; Rothwell, Peter; Boncoraglio, Giorgio; Thijs, Vincent; Levi, Chris; Meschia, James; Rosand, Jonathan; Kittner, Steven; Mitchell, Braxton; Dichgans, Martin; Worrall, Bradford; Markus, Hugh

doi:10.1002/ana.24840

Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke

Traylor M., Malik R., Nalls M. A., Cotlarciuc I., Radmanesh F., Thorleifsson G., ...Daha Fazla

ANNALS OF NEUROLOGY, cilt.81, sa.3, ss.383-394, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 81 Sayı: 3
Basım Tarihi: 2017
Doi Numarası: 10.1002/ana.24840
Dergi Adı: ANNALS OF NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.383-394
Hacettepe Üniversitesi Adresli: Hayır

Özet

Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS metaanalysis, including a large younger-onset SVS population, to identify novel associations with stroke.