Genetic Variation at 16q24.2 Is Associated With Small Vessel Stroke

Traylor M., Malik R., Nalls M. A., Cotlarciuc I., Radmanesh F., Thorleifsson G., ...More

ANNALS OF NEUROLOGY, vol.81, no.3, pp.383-394, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1002/ana.24840
  • Journal Name: ANNALS OF NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.383-394
  • Hacettepe University Affiliated: No

Abstract

Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS metaanalysis, including a large younger-onset SVS population, to identify novel associations with stroke.