Preparation and in vitro evaluation of meloxicam-loaded PLGA nanoparticles on HT-29 human colon adenocarcinoma cells

Sengel-Turk C. T., Hascicek C., DOĞAN A., ESENDAĞLI G., Guc D., Gonul N.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol.38, no.9, pp.1107-1116, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.3109/03639045.2011.641562
  • Journal Name: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1107-1116
  • Keywords: Nanoparticles, PLGA, PVA, cyclooxygenase-2, cytotoxicity, uptake, DRUG ENTRAPMENT EFFICIENCY, PARTICLE-SIZE, POLY(D,L-LACTIDE-CO-GLYCOLIDE) NANOPARTICLES, OSTEOSARCOMA CELLS, CONTROLLED-RELEASE, GROWTH-FACTOR, CANCER CELLS, INHIBITOR, DELIVERY, VIVO
  • Hacettepe University Affiliated: Yes

Abstract

Context: The inhibitors of cyclooxygenase (COX)-2 play an important role in cancer chemoprevention. Certain COX-2 inhibitors exert antiproliferative and pro-apoptotic effects on cancer cells.