Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats


KAZKAYASI İ. , Ismail M., Parrado-Fernandez C., Bjorkhem I., PEKİNER C. , Uma S., ...Daha Fazla

NEUROSCIENCE LETTERS, cilt.633, ss.174-181, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 633
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.neulet.2016.09.018
  • Dergi Adı: NEUROSCIENCE LETTERS
  • Sayfa Sayıları: ss.174-181

Özet

Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet.