Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

KAZKAYASI İ., Ismail M., Parrado-Fernandez C., Bjorkhem I., PEKİNER C., Uma S., ...More

NEUROSCIENCE LETTERS, vol.633, pp.174-181, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 633
  • Publication Date: 2016
  • Doi Number: 10.1016/j.neulet.2016.09.018
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.174-181
  • Hacettepe University Affiliated: Yes


Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet.