Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

KAZKAYASI, İNCİ; Ismail, Muhammad-Al-Mustafa; Parrado-Fernandez, Cristina; Bjorkhem, Ingemar; PEKİNER, CAN; Uma, Serdar; Cedazo-Minguez, Angel; Burul-Bozkurt, Nihan

doi:10.1016/j.neulet.2016.09.018

Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

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KAZKAYASI İ., Ismail M., Parrado-Fernandez C., Bjorkhem I., PEKİNER C., Uma S., ...More

NEUROSCIENCE LETTERS, vol.633, pp.174-181, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 633
Publication Date: 2016
Doi Number: 10.1016/j.neulet.2016.09.018
Journal Name: NEUROSCIENCE LETTERS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.174-181
Hacettepe University Affiliated: Yes

Abstract

Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms behind this association is not clear yet.