The effects of an insertion in the 5 ' UTR of the AMCase on gene expression and pulmonary functions

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BİRBEN E., SAÇKESEN C., KAZANİ S., Tincer G., KARAASLAN İ. Ç., DURGUNSU B., ...More

RESPIRATORY MEDICINE, vol.105, no.8, pp.1160-1169, 2011 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 105 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1016/j.rmed.2011.03.017
  • Journal Name: RESPIRATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1160-1169
  • Keywords: Asthma, Chitinase, Genetics, Polymorphism, Pulmonary function, Severity, ACIDIC MAMMALIAN CHITINASE, SERUM IGE LEVELS, HUMAN LUNG, CD14, POLYMORPHISMS, ASTHMA, FAMILY, CHILDHOOD, CHILDREN, CHITOTRIOSIDASE
  • Open Archive Collection: AVESIS Open Access Collection
  • Hacettepe University Affiliated: Yes

Abstract

Background: Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the effects of its genetic variants on asthma have produced conflicting results.