Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)(2)Cl-2] complexes


Gumus F., Demirci A., Ozden T., Eroglu H., Diril N.

PHARMAZIE, vol.58, no.5, pp.303-307, 2003 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 5
  • Publication Date: 2003
  • Journal Name: PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.303-307

Abstract

In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)(2)Cl-2] (ligand=2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole (3) were synthesized and characterized by their elemental analysis, and IR and H-1 NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102.