Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases


Ünüvar S., Erge D., Kılıçarslan B. , Bağ H., Çatal F., Girgin G. , ...More

ANNALS OF LABORATORY MEDICINE, vol.39, no.3, pp.284-290, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.3343/alm.2019.39.3.284
  • Title of Journal : ANNALS OF LABORATORY MEDICINE
  • Page Numbers: pp.284-290

Abstract

Background: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-gamma) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity.