Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases

Ünüvar S., Erge D., Kılıçarslan B., Bağ H., Çatal F., Girgin G., ...More

ANNALS OF LABORATORY MEDICINE, vol.39, no.3, pp.284-290, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.3343/alm.2019.39.3.284
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.284-290
  • Keywords: Allergy, Kynurenine, Neopterin, Tryptophan, Atopic dermatitis, Allergic rhinitis, Asthma, Th1 immune response, indoleamine 2,3-dioxygenase activity, TRYPTOPHAN DEGRADATION, KYNURENINE PATHWAY, SERUM TRYPTOPHAN, INFLAMMATION, CANCER
  • Hacettepe University Affiliated: Yes


Background: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-gamma) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity.