Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases
ANNALS OF LABORATORY MEDICINE, cilt.39, sa.3, ss.284-290, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 39 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.3343/alm.2019.39.3.284
- Dergi Adı: ANNALS OF LABORATORY MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.284-290
- Anahtar Kelimeler: Allergy, Kynurenine, Neopterin, Tryptophan, Atopic dermatitis, Allergic rhinitis, Asthma, Th1 immune response, indoleamine 2,3-dioxygenase activity, TRYPTOPHAN DEGRADATION, KYNURENINE PATHWAY, SERUM TRYPTOPHAN, INFLAMMATION, CANCER
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-gamma) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity.