Wilms Tumor, AML and Medulloblastoma in a Child With Cancer Prone Syndrome of Total Premature Chromatid Separation and Fanconi Anemia

Sari N., AKYÜZ C., Aktas D., GÜMRÜK F., ORHAN D., ALİKAŞİFOĞLU M., ...More

PEDIATRIC BLOOD & CANCER, vol.53, no.2, pp.208-210, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1002/pbc.21966
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.208-210
  • Hacettepe University Affiliated: Yes


Wilms tumor (WT) is the most common primary renal tumor in childhood. The Occurrence of WT in patients with growth retardation, mental retardation and central nervous system abnormalities in association with premature chromatid separation (PCS) and mosaic variegated aneuploidy has been previously described in only 10 patients. Here we report the very rare occurrence of WT with two other malignancies, acute myeloid leukemia and medulloblastoma in association with chromosomal instability. This is a novel presentation of Fanconi anemia with this cytogenetic abnormality. Pediatr Blood Cancer 2009;53:208-210. (C) 2009 Wiley-Liss, Inc.