Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation
JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.68, no.8, pp.1010-1020, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 68 Issue: 8
- Publication Date: 2016
- Doi Number: 10.1111/jphp.12587
- Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1010-1020
- Hacettepe University Affiliated: Yes
Abstract
ObjectiveOcular diseases affecting retina, such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma are the major causes of blindness, and their treatment is still a challenge due to the special structure of the eye. The purpose of this study was to prepare a sustained release DEX conjugate formulation with enhanced ocular permeation using poly(amidoamine) (PAMAM) dendrimers and to evaluate the effects of conjugation on DEX release and ocular residence time.