Dexamethasone - PAMAM dendrimer conjugates for retinal delivery: preparation, characterization and in vivo evaluation

Yavuz B., Pehlivan S., Bolu B. S., Sanyal R. N., VURAL İ., UNLU N.

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.68, no.8, pp.1010-1020, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1111/jphp.12587
  • Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1010-1020
  • Hacettepe University Affiliated: Yes

Abstract

ObjectiveOcular diseases affecting retina, such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma are the major causes of blindness, and their treatment is still a challenge due to the special structure of the eye. The purpose of this study was to prepare a sustained release DEX conjugate formulation with enhanced ocular permeation using poly(amidoamine) (PAMAM) dendrimers and to evaluate the effects of conjugation on DEX release and ocular residence time.