Formulation and In Vitro Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Technique

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ÖZTÜRK N., KARA A., VURAL İ.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.5, pp.492-499, 2020 (ESCI, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 17 Issue: 5
• Publication Date: 2020
• Doi Number: 10.4274/tjps.galenos.2019.76402
• Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
• Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
• Page Numbers: pp.492-499
• Open Archive Collection: AVESIS Open Access Collection
• Hacettepe University Affiliated: Yes

Abstract

Objectives: Telmisartan (TLM) is an antihypertensive drug that has been shown to have antiproliferative effects on cancer cells. It has low solubility and suboptimal oral bioavailability. To investigate the potential anticancer effect of TLM on breast cancer cells, poly (D, L-lactide) (PLA) nanoparticles were formulated with the benefit of improving its solubility.