Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies

Sahoo, Anasuya; YABANOĞLU ÇİFTÇİ, SAMİYE; Sinha, Barij; UÇAR, GÜLBERK; Basu, Arijit; Jayaprakash, Venkatesan

doi:10.1016/j.bmcl.2009.11.015

Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies

Atıf İçin Kopyala

Sahoo A., YABANOĞLU ÇİFTÇİ S., Sinha B. N., UÇAR G., Basu A., Jayaprakash V.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.20, sa.1, ss.132-136, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 1
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.bmcl.2009.11.015
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.132-136
Hacettepe Üniversitesi Adresli: Evet

Özet

Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values. (C) 2009 Elsevier Ltd. All rights reserved.