Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies


Sahoo A., YABANOĞLU ÇİFTÇİ S. , Sinha B. N. , UÇAR G. , Basu A., Jayaprakash V.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.20, sa.1, ss.132-136, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Konu: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.bmcl.2009.11.015
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Sayfa Sayıları: ss.132-136

Özet

Ten novel 3,5-diaryl pyrazolines were synthesized and investigated for their monoamine oxidase (MAO) inhibitory property. All the molecules were found to be reversible and selective inhibitor for either one of the isoform (MAO-A or MAO-B). Further insights in the theoretical evaluation of the possible interactions between the compounds and monoamine oxidases (MAO-A or MAO-B) have been developed through docking studies. The theoretical values are in congruence with their experimental values. (C) 2009 Elsevier Ltd. All rights reserved.