Effect of erythrocytes on the hepatic distribution kinetics of antipyrine


Sahin S., Rowland M.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, sa.1, ss.37-41, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/bf03190572
  • Dergi Adı: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Sayfa Sayıları: ss.37-41

Özet

The role of erythrocyte on the hepatic distribution kinetics of antipyrine was investigated in the in situ isolated perfused rat liver. Perfusion experiments were conducted using Krebs-bicarbonate buffer delivered via the portal vein in a single pass mode at a total flow rate of 15 ml/min. A bolus dose of antipyrine was administered in the presence and absence of erythrocytes. Almost identical moment analysis results (without erythrocytes mean transit time, MTT: 23 s; volume of distribution, V(H): 0.57 ml/g liver and with erythrocytes, MTT: 24 s; V(H) : 0.60 ml/g liver) and superimposable unimodal effluent curves were obtained in the presence and absence of erythrocytes indicates that distribution kinetics of antipyrine within the liver is not affected by erythrocytes.