Akademik Veri Yönetim Sistemi
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, sa.1, ss.37-41, 2004 (SCI-Expanded)
The role of erythrocyte on the hepatic distribution kinetics of antipyrine was investigated in the in situ isolated perfused rat liver. Perfusion experiments were conducted using Krebs-bicarbonate buffer delivered via the portal vein in a single pass mode at a total flow rate of 15 ml/min. A bolus dose of antipyrine was administered in the presence and absence of erythrocytes. Almost identical moment analysis results (without erythrocytes mean transit time, MTT: 23 s; volume of distribution, V(H): 0.57 ml/g liver and with erythrocytes, MTT: 24 s; V(H) : 0.60 ml/g liver) and superimposable unimodal effluent curves were obtained in the presence and absence of erythrocytes indicates that distribution kinetics of antipyrine within the liver is not affected by erythrocytes.