In vitro effects of rosmarinic acid on glutathione reductase and glucose 6-phosphate dehydrogenase

TANDOGAN B., KURUUZUM-UZ A., SENGEZER C., GÜVENALP Z., DEMİREZER L. Ö., ULUSU N. N.

PHARMACEUTICAL BIOLOGY, cilt.49, sa.6, ss.587-594, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/13880209.2010.533187
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.587-594
  • Anahtar Kelimeler: Enzyme inhibition, kinetics, natural product, purification, NATURAL PHENOLIC-COMPOUNDS, PURIFICATION, BINDING, KIDNEY, ANTIOXIDANT, DERIVATIVES, MECHANISM, SUBSTRATE, KINETICS, AMYLASE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Context: Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E. C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, glucose 6-phosphate (G6P):NADP(+) oxidoreductase, EC 1.1.1.49) is the key regulatory enzyme of the pentose phosphate pathway and maintains NADPH for reductive reactions.