Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

Tang J., Erdener S. E., Fu B., Boas D. A.

OPTICS LETTERS, cilt.42, sa.19, ss.3976-3979, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 19
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1364/ol.42.003976
  • Dergi Adı: OPTICS LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3976-3979
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift of flowing RBCs. The angular frequency of the signal from flowing RBCs was then quantified from the dynamic component of the signal and used to calculate the axial speed of flowing RBCs in capillaries. We validated our measurement by RBC passage velocimetry using the signal magnitude of the same OCT time series data. (C) 2017 Optical Society of America