THE USE OF IGM-ENRICHED INTRAVENOUS IMMUNOGLOBULIN FOR THE TREATMENT OF NEONATAL SEPSIS IN PRETERM INFANTS

ERDEM G., YURDAKOK M., TEKINALP G., ERSOY F.

TURKISH JOURNAL OF PEDIATRICS, vol.35, no.4, pp.277-281, 1993 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 1993
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.277-281
  • Hacettepe University Affiliated: Yes

Abstract

The value of IgM-enriched immunoglobulin therapy in 44 preterm infants with neonatal sepsis was evaluated in a prospective randomized study. All infants received antibiotic therapy and fresh plasma and / or whole blood transfusions. Twenty randomly-chosen infants were allocated to receive 5 ml / kg / d of IgM-enriched immunoglobulin intravenously for three days. Although the mortality rate in preterm infants whose gestational ages were 31-34 weeks in the immunotherapy group was slightly lower than in the control group, the general mortality rate from sepsis in the control group 19 / 24) and in the immunotherapy group (6 / 20) showed no statistically significant difference (37.5% vs 30.0%, p < 0.05).