Hydrogen peroxide-induced stroke: Elucidation of the mechanism in vivo - Laboratory investigation

Mut M. , Yemisci M. , Gursoy-Ozdemir Y., Ture U.

Journal of Neurosurgery, cilt.110, sa.1, ss.94-100, 2009 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 110 Konu: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3171/2008.3.17434
  • Dergi Adı: Journal of Neurosurgery
  • Sayfa Sayıları: ss.94-100


Object. Hydrogen peroxide (H(2)O(2)) is used as a hemostatic agent in many neurosurgery centers. The authors used a 3% H(2)O(2) solution for final hemostasis after removal of a left insular tumor. Immediately afterward, air bubbles were observed within the lumen of the polar temporal artery. Postoperative MR imaging revealed punctate areas of infarction in the lenticulostriate artery territory. The authors designed an experimental Study to elucidate the mechanism of remote O(2) emboli and reactive O(2) species-related vasoactive responses and thrombus formation.