Hydrogen peroxide-induced stroke: Elucidation of the mechanism in vivo - Laboratory investigation

Mut M., Yemisci M., Gursoy-Ozdemir Y., Ture U.

Journal of Neurosurgery, cilt.110, sa.1, ss.94-100, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 110 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.3171/2008.3.17434
  • Dergi Adı: Journal of Neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.94-100
  • Anahtar Kelimeler: hydrogen peroxide, insula, lenticulostriate artery, mouse, oxygen embolus, peroxynitrite, stroke, thrombus, FOCAL CEREBRAL-ISCHEMIA, NADPH-OXIDASE ACTIVITY, SMOOTH-MUSCLE-CELLS, NITRIC-OXIDE, ENDOTHELIAL-CELLS, CASE ILLUSTRATION, OXYGEN EMBOLISM, FREE-RADICALS, K+ CHANNELS, PEROXYNITRITE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Object. Hydrogen peroxide (H(2)O(2)) is used as a hemostatic agent in many neurosurgery centers. The authors used a 3% H(2)O(2) solution for final hemostasis after removal of a left insular tumor. Immediately afterward, air bubbles were observed within the lumen of the polar temporal artery. Postoperative MR imaging revealed punctate areas of infarction in the lenticulostriate artery territory. The authors designed an experimental Study to elucidate the mechanism of remote O(2) emboli and reactive O(2) species-related vasoactive responses and thrombus formation.