Toxicity of acrylamide and evaluation of its exposure in baby foods

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Erkekoglu P., BAYDAR T.

NUTRITION RESEARCH REVIEWS, cilt.23, sa.2, ss.323-333, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1017/s0954422410000211
  • Dergi Adı: NUTRITION RESEARCH REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.323-333
  • Anahtar Kelimeler: Acrylamide, Baby food, Infant formulas, Toxicity, EPOXIDE METABOLITE GLYCIDAMIDE, PERIPHERAL NERVOUS-SYSTEM, TANDEM MASS-SPECTROMETRY, REPRODUCTIVE TOXICITY, ADDUCT FORMATION, DEVELOPMENTAL TOXICITY, HEMOGLOBIN ADDUCTS, GERMAN CHILDREN, DRINKING-WATER, DIETARY-INTAKE
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Contaminants are a vast subject area of food safety and quality and can be present in our food chain from raw materials to finished products. Acrylamide, an alpha,beta-unsaturated (conjugated) reactive molecule, can be detected as a contaminant in several foodstuffs including baby foods and infant formulas. It is anticipated that children will generally have intakes that are two to three times those of adults when expressed on a body-weight basis. Though exposure to acrylamide is inevitable, it is necessary to protect infant and children from high exposure. The present review focuses on the several adverse health effects of acrylamide including mutagenicity, genotoxicity, carcinogenicity, neurotoxicity and reproductive toxicity, and the possible outcomes of childhood exposure from baby foods and infant formulas.