Systemic treatment in breast-cancer patients with brain metastasis


Arslan C. , DİZDAR Ö. , Altundag K.

EXPERT OPINION ON PHARMACOTHERAPY, cilt.11, ss.1089-1100, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1517/14656561003702412
  • Dergi Adı: EXPERT OPINION ON PHARMACOTHERAPY
  • Sayfa Sayıları: ss.1089-1100

Özet

Areas covered in this review: Standard therapy for brain metastasis is currently whole-brain radiotherapy. Other treatment modalities include surgery and radiosurgery in selected cases, corticosteroids, and systemic chemotherapy. Little progress has been made in chemotherapy for the treatment of brain metastases, partly because tumors develop brain metastases at a stage when they become totally chemoresistant. Nevertheless, new treatment choices have emerged considering cytotoxic and biological agents for the treatment of CNS metastases in patients with breast cancer.