Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus

Batu E. D., Koşukcu C., Taşkıran E., Sahin S., Akman S., Sözeri B., ...Daha Fazla

JOURNAL OF RHEUMATOLOGY, cilt.45, sa.12, ss.1671-1679, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3899/jrheum.171358
  • Dergi Adı: JOURNAL OF RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1671-1679
  • Anahtar Kelimeler: EARLY-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS, MONOGENIC, COMPLEMENT SYSTEM, WHOLE EXOME SEQUENCING, HUMAN C1Q DEFICIENCY, MOLECULAR-BASIS, SUSCEPTIBILITY VARIANTS, CLINICAL PRESENTATION, C-CHAINS, A-CHAINS, GENES, IDENTIFICATION, ASSOCIATION, VALIDATION
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. Early-onset, familial, and/or syndromic SLE may reveal monogenic pathologies. The aim of this study was to examine genetic associations in patients with early-onset or familial SLE.