Quantification of Moxifloxacin and Levofloxacin in Curettage Material by SPE-LC
CHROMATOGRAPHIA, cilt.71, ss.1147-1150, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 71
- Basım Tarihi: 2010
- Doi Numarası: 10.1365/s10337-010-1596-8
- Dergi Adı: CHROMATOGRAPHIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1147-1150
- Hacettepe Üniversitesi Adresli: Evet
Özet
Moxifloxacin and levofloxacin have been quantified in dilatation and curettage samples by reversed-phase LC. High recovery (> 91%) was obtained by simple and efficient solid-phase extraction. The method was validated in accordance with ICH guidelines to confirm specificity, linearity, accuracy, and precision. Response was a linear function of concentration over the range 0.010-30 mu g g(-1) with excellent correlation coefficients (> 0.997). Intra-day and inter-day precision and accuracy over the entire concentration range were less than 6.40 and 7.38%, respectively. Finally, the validated method was used for analysis of moxifloxacin and levofloxacin in dilatation and curettage material obtained from unwanted pregnancies up to 10 weeks gestation.