Update on ADAMTS13 and VWF in cardiovascular and hematological disorders

Akyol O. , Akyol S., Chen C.

CLINICA CHIMICA ACTA, cilt.463, ss.109-118, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 463
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cca.2016.10.017
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Sayfa Sayıları: ss.109-118

Özet

Endothelial cells (EC) respond to injury by releasing numerous factors, including von Willebrand factor (VWF). High circulating levels of unusually large VWF multimers (UL-VWFM) have strong procoagulant activity and facilitate platelet adhesion and aggregation by interacting with platelets after an acute event superimposed on peripheral arterial disease and coronary artery disease.