Update on ADAMTS13 and VWF in cardiovascular and hematological disorders

Akyol O., Akyol S., Chen C.

CLINICA CHIMICA ACTA, vol.463, pp.109-118, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 463
  • Publication Date: 2016
  • Doi Number: 10.1016/j.cca.2016.10.017
  • Journal Name: CLINICA CHIMICA ACTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.109-118
  • Hacettepe University Affiliated: Yes

Abstract

Endothelial cells (EC) respond to injury by releasing numerous factors, including von Willebrand factor (VWF). High circulating levels of unusually large VWF multimers (UL-VWFM) have strong procoagulant activity and facilitate platelet adhesion and aggregation by interacting with platelets after an acute event superimposed on peripheral arterial disease and coronary artery disease.