Advances in stroke neuroprotection: Hyperoxia and beyond

Singhal A., Lo E., Dalkara T., Moskowitz M.

NEUROIMAGING CLINICS OF NORTH AMERICA, cilt.15, sa.3, ss.697-722, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.nic.2005.08.014
  • Dergi Adı: NEUROIMAGING CLINICS OF NORTH AMERICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.697-722
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Refinements in patient selection, improved methods of drug delivery, use of more clinically relevant animal stroke models, and the use of combination therapies that target the entire neurovascular unit make stroke neuroprotection an achievable goal. This article provides an overview of the major mechanisms of neuronal injury and the status of neuroprotective drug trials and reviews emerging strategies for treatment of acute ischemic stroke. Advances in the fields of stem cell transplantation, stroke recovery, molecular neuroimaging, genomics, and proteomics will provide new therapeutic avenues in the near future. These and other developments over the past decade raise expectations that successful stroke neuroprotection is imminent.