The expression and clinical effects of alpha-methylacyl-CoA racemase (AMACR/P504S) as an immunohistochemical marker in malign pleural mesothelioma

Duyar S. S., Yilmaz A., Demirag F., Erdogan Y., Yazici U., Karakaya J.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.3, pp.607-614, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1404-28
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.607-614
  • Hacettepe University Affiliated: Yes

Abstract

Background/aim: Alpha-methylacyl-CoA racemase (AMACR), an intracellular enzyme involved in lipid metabolism, has emerged as an immunohistochemical marker for many types of cancer. Recent studies about the role of lipid metabolism in pathogenesis of mesothelioma have brought up some positive results. This study was conducted to investigate AMACR expression in the diagnosis of malignant pleural mesothelioma (MPM) and the correlation of this marker with clinical characteristics and survival.