The expression and clinical effects of alpha-methylacyl-CoA racemase (AMACR/P504S) as an immunohistochemical marker in malign pleural mesothelioma


Duyar S. S. , Yilmaz A., Demirag F., Erdogan Y., Yazici U., Karakaya J.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, ss.607-614, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1404-28
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.607-614

Özet

Background/aim: Alpha-methylacyl-CoA racemase (AMACR), an intracellular enzyme involved in lipid metabolism, has emerged as an immunohistochemical marker for many types of cancer. Recent studies about the role of lipid metabolism in pathogenesis of mesothelioma have brought up some positive results. This study was conducted to investigate AMACR expression in the diagnosis of malignant pleural mesothelioma (MPM) and the correlation of this marker with clinical characteristics and survival.