Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

Tasdemir, D; Mangalindan, GC; Concepcion, GP; Verbitski, SM; Rabindran, S; Miranda, M; Greenstein, M; Hooper, JNA; Harper, MK; Ireland, CM

doi:10.1021/np0104020

Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

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Tasdemir D., Mangalindan G., Concepcion G., Verbitski S., Rabindran S., Miranda M., ...More

JOURNAL OF NATURAL PRODUCTS, vol.65, no.2, pp.210-214, 2002 (SCI-Expanded)

Publication Type: Article / Article
Volume: 65 Issue: 2
Publication Date: 2002
Doi Number: 10.1021/np0104020
Journal Name: JOURNAL OF NATURAL PRODUCTS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.210-214
Hacettepe University Affiliated: No

Abstract

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1)/(Cipl)-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 muM, respectively.