Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata

Tasdemir D., Mangalindan G., Concepcion G., Verbitski S., Rabindran S., Miranda M., ...Daha Fazla

JOURNAL OF NATURAL PRODUCTS, cilt.65, sa.2, ss.210-214, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1021/np0104020
  • Dergi Adı: JOURNAL OF NATURAL PRODUCTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.210-214
  • Hacettepe Üniversitesi Adresli: Hayır

Özet

Two new isomalabaricane triterpenes, stellettin H (1) and stellettin I (2), have been isolated from the marine sponge Rhabdastrella globostellata, collected from the Philippines. Stellettins A-D (3-6), (-)stellettin E (7), and rhabdastrellic acid-A (8) were also isolated and characterized. Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1)/(Cipl)-deficient human colon tumor (HCT-116) cells with IC50 values of 0.043 and 0.039 muM, respectively.