Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells


Hakki S. S. , Hakki E. E. , Nohutcu R. M.

JOURNAL OF PERIODONTAL RESEARCH, vol.44, no.6, pp.794-802, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1111/j.1600-0765.2008.01192.x
  • Title of Journal : JOURNAL OF PERIODONTAL RESEARCH
  • Page Numbers: pp.794-802

Abstract

Background and Objectives: In this study, we investigated the effect of basic fibroblast growth factor (bFGF) and dexamethasone (Dex) on mRNA expressions of collagen (COL) type I, III and X, matrix metalloproteinases (MMP)-1, -2, -3 and -9 and tissue inhibitors of metalloproteinases (TIMP)-1 and -2, and also on mineralization and morphology of periodontal ligament (PDL) cells.