Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells

Hakki, S.; Hakki, E.; Nohutcu, R.

doi:10.1111/j.1600-0765.2008.01192.x

Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells

Copy For Citation

Hakki S. S., Hakki E. E., Nohutcu R. M.

JOURNAL OF PERIODONTAL RESEARCH, vol.44, no.6, pp.794-802, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 44 Issue: 6
Publication Date: 2009
Doi Number: 10.1111/j.1600-0765.2008.01192.x
Journal Name: JOURNAL OF PERIODONTAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.794-802
Hacettepe University Affiliated: Yes

Abstract

Background and Objectives: In this study, we investigated the effect of basic fibroblast growth factor (bFGF) and dexamethasone (Dex) on mRNA expressions of collagen (COL) type I, III and X, matrix metalloproteinases (MMP)-1, -2, -3 and -9 and tissue inhibitors of metalloproteinases (TIMP)-1 and -2, and also on mineralization and morphology of periodontal ligament (PDL) cells.