Purpose: The purpose of this study was to investigate the reliability and validity of the Turkish version of Satisfaction with the Prosthesis (SATPRO) Questionnaire. Material and methods: Forty amputees with unilateral lower extremity amputation were included in the study. The SATPRO and the Nottingham Health Profile (NHP) were administered to the volunteers. ICC (Intraclass Correlation coefficient) was used for reliability and the correlation between the subscales of the NHP and SATPRO were used to analyze concurrent validity. Results: The Turkish version of the SATPRO Questionnaire was found to give significantly reliable results for test and retest (ICC=0.903). Physical Activity and Pain subscales of the NHP were also correlated to the SATPRO results (p<0.05). Conclusion: This study showed that the Turkish version of the SATPRO is a valid and reliable instrument for use in unilateral lower extremity amputees.