Does tamoxifen citrate prevent pulmonary fibrosis due to silica inhalation?

Karaca, T.; Yoldas, O.; Bilgin, B.; Yilmaz, O.; Karaca, N.; Simsek, G.; Alici, I.; Uzdogan, A.; Tezer, A.; Comert, M.; Akin, T.; Kismet, K.; Tutkun, E.; Akbiyik, FİLİZ

doi:10.4149/bll_2015_083

Does tamoxifen citrate prevent pulmonary fibrosis due to silica inhalation?

Karaca T., Yoldas O., Bilgin B. C., Yilmaz O. H., Karaca N., Simsek G. G., ...Daha Fazla

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.116, sa.7, ss.440-445, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 116 Sayı: 7
Basım Tarihi: 2015
Doi Numarası: 10.4149/bll_2015_083
Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.440-445
Hacettepe Üniversitesi Adresli: Evet

Özet

BACKGROUND: As shown in several studies, besides being used in breast cancer, tamoxifen is also known for its antifibrotic effects via reducing the serum TGF-beta levels. We investigated the possible preventive effect of tamoxifen in rats exposed to silica particles depending on the antifibrotic effect.