Does tamoxifen citrate prevent pulmonary fibrosis due to silica inhalation?


Karaca T., Yoldas O., Bilgin B. C., Yilmaz O. H., Karaca N., Simsek G. G., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.7, pp.440-445, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

BACKGROUND: As shown in several studies, besides being used in breast cancer, tamoxifen is also known for its antifibrotic effects via reducing the serum TGF-beta levels. We investigated the possible preventive effect of tamoxifen in rats exposed to silica particles depending on the antifibrotic effect.