Does tamoxifen citrate prevent pulmonary fibrosis due to silica inhalation?


Karaca T., Yoldas O., Bilgin B. C. , Yilmaz O. H. , Karaca N., Simsek G. G. , ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.116, no.7, pp.440-445, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 7
  • Publication Date: 2015
  • Doi Number: 10.4149/bll_2015_083
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.440-445

Abstract

BACKGROUND: As shown in several studies, besides being used in breast cancer, tamoxifen is also known for its antifibrotic effects via reducing the serum TGF-beta levels. We investigated the possible preventive effect of tamoxifen in rats exposed to silica particles depending on the antifibrotic effect.