Prevalence of confirmed immediate type drug hypersensitivity reactions among school children


ERKOCOGLU M., KAYA A., Civelek E. , OZCAN C., ÇAKIR B. , AKAN A., ...Daha Fazla

PEDIATRIC ALLERGY AND IMMUNOLOGY, cilt.24, ss.160-167, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1111/pai.12047
  • Dergi Adı: PEDIATRIC ALLERGY AND IMMUNOLOGY
  • Sayfa Sayıları: ss.160-167

Özet

Background Despite drug-related hypersensitivity reactions are an important health problem, epidemiologic data on drug allergy and hypersensitivity are limited, and studies including diagnostic work-up are scarce. The aim of this study was to determine the actual frequency of immediate type drug hypersensitivity using diagnostic tests in school children with parent-reported drug allergies. Methods This study involved three phases. The first phase is a survey of children with a mean age of 12.9yrs attending grades 68 of primary schools with a questionnaire asking drug-related symptoms within 2h of ingestion. The total population of sixth to eight grade school children was 210,000, and a sample size of 9096 was deemed to be representative of Ankara [(p)=1.0%, <0.05, =0.8, (d)=0.2.] During the second phase, a detailed clinical history was obtained by phone from the parents of children who had positive parent-reported drug allergy. The final stage of the study consisted of a detailed diagnostic work-up of children with a clinical history consistent with immediate type drug hypersensitivity reaction. Results Overall, 11,233 questionnaires were distributed, 10,096 of which were retrieved after completion by parents. The rate of parent-reported immediate type drug hypersensitivity was 7.87% (792 children). However, phone survey revealed a clinical history suggestive of drug allergy in only 117 children (1.16%). After further diagnostic work-up, the true frequency of immediate type drug hypersensitivity was 0.11%. Conclusion Our results suggest that a positive clinical history is not enough to make a diagnosis of drug allergy, which highlights the significance of undertaking further diagnostic evaluation.