Methylprednisolone Induce Terminal Differentiation in the U-937 Human Myelomonocytic Leukemia Cells
TURKISH JOURNAL OF IMMUNOLOGY, cilt.13, sa.1, ss.10-14, 2008 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 1
- Basım Tarihi: 2008
- Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.10-14
- Hacettepe Üniversitesi Adresli: Evet
Özet
Differentiation studies have shown that methylprednisolone have some roles onto the leukemia cell line such as HL-60 and K-562. Methylprednisolone (MP), a steroid compound, binds the nuclear glucocorticoid receptor and regulates the transcription. In this study, differentiation effect of methylprednisolone on human monocytic leukemia (U-937) cell line was investigated for two types of cluster differentiation (CD11b, CD68) markers by using flow cytometry. It was observed that the significant terminal differentiation of U-937 cells occured after treatment with high dose (10-3 M) MP for 24 and 48 hrs. Our data points out that MP is a differentiation inducing agent for myelomonocytic leukemic cells and could be potential treating compound in other type of leukemic cell differentiation.