Vasculitis in children


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Eleftheriou D., Batu E. D. , ÖZEN S., Brogan P. A.

NEPHROLOGY DIALYSIS TRANSPLANTATION, vol.30, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 30
  • Publication Date: 2015
  • Doi Number: 10.1093/ndt/gfu393
  • Journal Name: NEPHROLOGY DIALYSIS TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: children, clinical trials, systemic vasculitis, vasculitis outcome measures, HENOCH-SCHONLEIN PURPURA, ANTINEUTROPHIL CYTOPLASMIC ANTIBODY, CHILDHOOD POLYARTERITIS-NODOSA, RHEUMATOLOGY 1990 CRITERIA, CHURG-STRAUSS-SYNDROME, TAKAYASU ARTERITIS, FOLLOW-UP, MICROSCOPIC POLYANGIITIS, JUVENILE POLYARTERITIS, WEGENER GRANULOMATOSIS

Abstract

Primary systemic vasculitides of the young are relatively rare diseases, but are associated with significant morbidity and mortality, particularly if there is diagnostic delay. We provide an overview of paediatric vasculitides with emphasis on key differences in vasculitis presentation and management between children and adults. Significant advances in the field of paediatric vasculitis research include the development of classification criteria and disease outcome tools for paediatric disease; inclusion of paediatric patients in international multicentre randomized controlled trials of therapies in vasculitis; and development of rare disease trial designs for therapeutic trials of paediatric vasculitis. The continuation of unmet needs as well as the exploration of potential therapeutic avenues and considerations in the design of future trials are also discussed.