Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto's thyroiditis


SUR Ü. , Erkekoglu P. , Bulus A. D. , Andiran N., Kocer-Gumusel B.

TOXICOLOGY MECHANISMS AND METHODS, vol.29, no.9, pp.633-643, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.1080/15376516.2019.1646367
  • Title of Journal : TOXICOLOGY MECHANISMS AND METHODS
  • Page Numbers: pp.633-643

Abstract

In this study, we aimed to investigate whether bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with Hashimoto's thyroiditis (HT) and its biomarkers and to determine whether oxidative stress biomarkers and trace element levels showed any alterations in children with HT. We found that superoxide dismutase and glutathione peroxidase activities are lower in HT group from control (24% and 46%, respectively, p < 0.05). Zinc levels were significantly lower in HT group vs. control. In addition, the levels of mono-(2-ethylhexyl) phthalate (MEHP) which is the primary metabolite for DEHP, were markedly higher in HT group compared to control (p < 0.05). A negative correlation was observed between urinary BPA levels and fT4. In children with HT, oxidant/antioxidant balance is changed and these differences may be related by EDC exposure, the importance of which should be elucidated with further studies.