Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto's thyroiditis

SUR Ü., Erkekoglu P., Bulus A. D., Andiran N., Kocer-Gumusel B.

TOXICOLOGY MECHANISMS AND METHODS, cilt.29, sa.9, ss.633-643, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 9
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/15376516.2019.1646367
  • Dergi Adı: TOXICOLOGY MECHANISMS AND METHODS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.633-643
  • Anahtar Kelimeler: Bisphenol A, di-(2-ethylhexyl) phthalate, Hashimoto's thyroiditis, iodine, oxidative stress, selenium, thyroid hormones, zinc, BISPHENOL-A LEVELS, AUTOIMMUNE-THYROIDITIS, SELENIUM SUPPLEMENTATION, MALONDIALDEHYDE LEVELS, PHTHALATE METABOLITES, NONGOITROUS CHILDREN, INCREASED PREVALENCE, ANTIOXIDANT STATUS, HORMONE-LEVELS, FOLLOW-UP
  • Hacettepe Üniversitesi Adresli: Evet

Özet

In this study, we aimed to investigate whether bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with Hashimoto's thyroiditis (HT) and its biomarkers and to determine whether oxidative stress biomarkers and trace element levels showed any alterations in children with HT. We found that superoxide dismutase and glutathione peroxidase activities are lower in HT group from control (24% and 46%, respectively, p < 0.05). Zinc levels were significantly lower in HT group vs. control. In addition, the levels of mono-(2-ethylhexyl) phthalate (MEHP) which is the primary metabolite for DEHP, were markedly higher in HT group compared to control (p < 0.05). A negative correlation was observed between urinary BPA levels and fT4. In children with HT, oxidant/antioxidant balance is changed and these differences may be related by EDC exposure, the importance of which should be elucidated with further studies.