Preparation of new molecularly imprinted quartz crystal microbalance hybride sensor system for 8-hydroxy-2 '-deoxyguanosine determination

SAY R., Gultekin A., Ozcan A. A., DENİZLİ A., Ersoz A.

ANALYTICA CHIMICA ACTA, cilt.640, ss.82-86, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 640
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.aca.2009.03.022
  • Dergi Adı: ANALYTICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.82-86
  • Hacettepe Üniversitesi Adresli: Evet

Özet

The routine measurement of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in biological samples is a difficult analytical problem due to the low levels of the analyte and complex matrix. A new 8-OHdG imprinted quartz crystal microbalance (QCM) sensor has been developed for selective determination of 8-OHdG in serum samples. To fulfil the desired results, we have used methacryloyl aminoantipyrine-Fe(III) [MAAP-Fe(III)] and methacryloyl histidine-Pt(II) [MAH-Pt(II)] as metal-chelating monomers via double metal coordination-chelation interactions for the preparation of additional selective molecular imprinted polymers (MIP).