The Role Of Endocrine Disruptors In Obesity: A Review


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Büyükdere Y.

International Asklepios Congress On Medicine, Nursing, Midwıfery, and Health Sciences, Aydın, Turkey, 15 - 17 May 2024, pp.94

  • Publication Type: Conference Paper / Summary Text
  • Doi Number: 10.5281/zenodo.11235292
  • City: Aydın
  • Country: Turkey
  • Page Numbers: pp.94
  • Hacettepe University Affiliated: Yes

Abstract

ABSTRACT

Obesity is an important public health issue that has reached pandemic proportions according to

epidemiological data. Positive energy balance, sedentary lifestyle, and overeating behaviour are risk

factors for obesity. Furthermore, recent studies revealed that there may be nontraditional risk factors in

the aetiology of obesity. In the scientific literature, an increasing number of chemical compounds

included in endocrine disruptors have been reported to be among these nontraditional risk factors and

are called obesogens. Currently, more than 50 chemical compounds have been reported as

environmental obesogens. Bisphenol A, phthalate derivatives, polychlorinated biphenyls,

perfluoroalkyl substances, parabens, dioxins, organotin compounds, acrylamide, polybrominated

diphenyl ethers, and polycyclic aromatic hydrocarbons are examples of possible obesogenic compounds

associated with obesity. Endocrine disrupting chemicals function by targeting various endocrine axes

in the body. Exposure to endocrine disruptors at different doses and durations is associated with changes

in adipogenesis and adipocyte cell size, increase in adipose tissue size, adipocyte differentiation, body

weight increase, obesity-related adipose tissue dysfunction, and impaired glucose tolerance. Besides,

dysregulation of appetite and satiety signaling, disruption of energy metabolism, mimicking, or

interfering with the actions of natural lipophilic hormones, and triggering inflammation in various

organs and tissues were also shown to be mechanisms mediating the effects of endocrine disrupting

chemicals on obesity. It is estimated that there are still metabolic pathways that have not yet been

elucidated. Therefore, more comprehensive studies are needed on this topic. In this context, the aim of

this review is to examine the possible associations between endocrine disruptors and obesity.

Keywords: Chemical, Endocrine Disruptor, Metabolism, Obesity.