PATHOPHYSIOLOGY OF ALZHEIMER'S DISEASE: EXPERIMENTAL AND GENETIC FINDINGS

Saka E.

TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, vol.13, pp.21-26, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Review
  • Volume: 13
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.21-26
  • Hacettepe University Affiliated: Yes

Abstract

The current knowledge on the pathogenesis of Alzheimer's disease is derived from studies on pathology, genetics,and in vivo and in vitro experimental studies. These studies point amiloid beta peptide (A beta) and tau as key molecules for the pathogenesis of the disease. These molecules either as aggregates that they form or most probably as oligomers lead to the disease specific neuro-degeneration. New genetic and experimetal studies are expected to disclose novel putative genes, molecules and pathways and further help our better understanding of the disease