PITUITARY, vol.18, no.1, pp.116-125, 2015 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Acromegaly, d3-GHR polymorphism, Diabetes mellitus, Cancer, GH, GESTATIONAL-AGE CHILDREN, GROWTH-FACTOR-I, GH REPLACEMENT THERAPY, INCREASED RESPONSIVENESS, GLUCOSE-METABOLISM, GENE POLYMORPHISM, DEFICIENT ADULTS, EXPRESSION, GENOTYPE, ISOFORMS
Purpose Exon 3-deleted GH receptor variant (d3-GHR) is associated with increased responsiveness to exogenous GH. The aim of this study was to determine the effect of d3-GHR polymorphism on the GH/IGF-1 relationship, clinical parameters, and comorbidity in acromegalic patients.