The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly

Cinar N., DAĞDELEN S., YORGUN H., CANPOLAT U., Kabakci G., Erbas T.

PITUITARY, cilt.18, sa.1, ss.116-125, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s11102-014-0564-y
  • Dergi Adı: PITUITARY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.116-125
  • Anahtar Kelimeler: Acromegaly, d3-GHR polymorphism, Diabetes mellitus, Cancer, GH, GESTATIONAL-AGE CHILDREN, GROWTH-FACTOR-I, GH REPLACEMENT THERAPY, INCREASED RESPONSIVENESS, GLUCOSE-METABOLISM, GENE POLYMORPHISM, DEFICIENT ADULTS, EXPRESSION, GENOTYPE, ISOFORMS
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Purpose Exon 3-deleted GH receptor variant (d3-GHR) is associated with increased responsiveness to exogenous GH. The aim of this study was to determine the effect of d3-GHR polymorphism on the GH/IGF-1 relationship, clinical parameters, and comorbidity in acromegalic patients.