The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly


Cinar N., DAĞDELEN S. , YORGUN H. , CANPOLAT U. , Kabakci G., Erbas T.

PITUITARY, cilt.18, ss.116-125, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 18 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s11102-014-0564-y
  • Dergi Adı: PITUITARY
  • Sayfa Sayıları: ss.116-125

Özet

Purpose Exon 3-deleted GH receptor variant (d3-GHR) is associated with increased responsiveness to exogenous GH. The aim of this study was to determine the effect of d3-GHR polymorphism on the GH/IGF-1 relationship, clinical parameters, and comorbidity in acromegalic patients.