The clinical and cardiometabolic effects of d3-growth hormone receptor polymorphism in acromegaly


Cinar N., DAĞDELEN S. , YORGUN H. , CANPOLAT U. , Kabakci G., Erbas T.

PITUITARY, vol.18, no.1, pp.116-125, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1007/s11102-014-0564-y
  • Title of Journal : PITUITARY
  • Page Numbers: pp.116-125
  • Keywords: Acromegaly, d3-GHR polymorphism, Diabetes mellitus, Cancer, GH, GESTATIONAL-AGE CHILDREN, GROWTH-FACTOR-I, GH REPLACEMENT THERAPY, INCREASED RESPONSIVENESS, GLUCOSE-METABOLISM, GENE POLYMORPHISM, DEFICIENT ADULTS, EXPRESSION, GENOTYPE, ISOFORMS

Abstract

Purpose Exon 3-deleted GH receptor variant (d3-GHR) is associated with increased responsiveness to exogenous GH. The aim of this study was to determine the effect of d3-GHR polymorphism on the GH/IGF-1 relationship, clinical parameters, and comorbidity in acromegalic patients.