Synthesis of some new pyridyl-ethylated benzoxazolinones with analgesic and anti-inflammatory activities
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.49, sa.9, ss.754-758, 1999 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 9
- Basım Tarihi: 1999
- Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
- Sayfa Sayıları: ss.754-758
- Hacettepe Üniversitesi Adresli: Evet
Özet
Twelve new 3-[2-(2- and/or 4-pyridyl)ethyl]benzoxazolinone derivatives have been synthesized by reacting 2- and/or 4-vinylpyridine and appropriate benzoxazolinones. Their chemical structures have been proven by IR, H-1-NMR and elemental analysis. Analgesic activities of these compounds were investigated by a modified Koster and constant temperature hot-plate test. Test results revealed that most of the compounds at 100 mg/kg dose level showed significant analgesic activities when compared to acetylsalicylic acid and morphine. Therefore the compounds were screened for their anti-inflammatory activities using the carrageenan hind paw edema test. Compounds 3-8 were found more active than indometacin. In gastric ulceration studies, any of the compounds showed no gastrointestinal bleeding at 100 mg/kg dose level.