Synthesis and hypnotic activity of new 4-thiazolidinone and 2-thioxo-4,5-imidazolidinedione derivatives
ARCHIV DER PHARMAZIE, cilt.332, sa.10, ss.343-347, 1999 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 332 Sayı: 10
- Basım Tarihi: 1999
- Dergi Adı: ARCHIV DER PHARMAZIE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.343-347
- Hacettepe Üniversitesi Adresli: Evet
Özet
Conventionally accessible 4-[(2-(3,4-dimethoxyphenyl)ethyl] -3-thiosemicarbazide .(2) was converted to new 1-substituted benzylidene/furfurylidene-4- [2-(3,4-dimethoxyphenyl)ethyl] -3-thiosemicarbazides (3) which furnished 2-(substituted benzylidene/furfurylidene)hydrazono-3-[2-(3,4-dimethoxyphenyl)ethyl]thiazolidin-4-ones (4) and 1-(substituted benzylidene/furfurylidene)-amino-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-thioxo-4, 5-imidazolidinediones (5) on reaction with chloroacetic acid and oxalyl chloride, respectively. The structure of 5 was confirmed by X-ray diffraction performed on 5a. 4 and 5 were evaluated for their potentiating effects on pentobarbital induced hypnosis. Most of the compounds caused remarkable increases in pentobarbital sleeping time.