CHEMISTRY & BIODIVERSITY, vol.19, no.8, 2022 (SCI-Expanded)
In the current study, some phenolic compounds, including acteoside, isoacteoside, echinacoside, and arenarioside purified and characterized from Plantago subulata. These compounds were tested for its antioxidant potential, including Fe3+ and Cu2+ reductive ability and Fe2+ chelating effects. The inhibitory effects of isolated phenolic compounds were tested towards human carbonic anhydrase I and II isoenzymes (hCA I and hCA II), butyrylcholinesterase (BChE) acetylcholinesterase (AChE), aldose reductase (AR) and alpha-glycosidase (alpha-gly). K-i values were found these compounds in range of 0.24 +/- 0.05-1.38 +/- 0.34 mu M against hCA I, 0.194 +/- 0.018-1.03 +/- 0.06 mu M against hCA II, 0.043 +/- 0.01-0.154 +/- 0.02 mu M against AChE, 3.92 +/- 1.08-11.93 +/- 4.45 mu M against BChE, 0.082 +/- 0.0008-1.68 +/- 0.42 mu M against AR, and 6.93 +/- 2.74-17.17 +/- 6.70 mu M against alpha-glycosidase. As a result, isolated compounds displayed inhibition effects against studied all metabolic enzymes. They are promising candidates for treating disorders like Alzheimer's disease, diabetes mellitus, glaucoma, leukemia, and epilepsy.