NUTRITION, vol.103-104, 2022 (SCI-Expanded)
Objectives: Osteosarcopenic obesity (OSO; also known as adiposity) is the combination of three critical condi-tions. This study aimed to define OSO using muscle ultrasonography (US), and examine the relationship between OSO and frailty compared with its constituent components.Methods: A total of160 geriatric patients with a body mass index of >= 30 were enrolled in the study. We obtained US measurements of the rectus femoris thickness and cross-sectional area (RFCSA). OSO was defined as the combination of low muscle function (defined by handgrip strength <27 kg in men and <16 kg in women), low muscle mass (RFCSA <5.22 cm2), and the clinical diagnosis of osteoporosis. The modified Fried Frailty Index and Clinical Frailty Scale were used to identify frailty.Results: The median age of participants was 72 y, and 83% (n = 137) were female. Patients were divided into four categories: Obese (n = 72; 43.6%), osteoporotic obese (n = 44; 26.7%), sarcopenic obese (n = 19; 11.5%), and osteosarcopenic obese (n = 25; 15.2%). In the subgroup analysis, the prevalence of frailty was signifi-cantly higher in the OSO group than in the other groups on both frailty scales (P < 0.05). The regression anal-ysis showed that OSO significantly increased frailty status when adjusted for confounders detailed in Table 1 (Fried Frailty Index: odds ratio: 5.10; 95% confidence interval, 1.669-15.132; P = 0.004; Clinical Frailty Scale: odds ratio: 3.765; 95% confidence interval, 1.236-11.465; P = 0.020).Conclusions: US-defined OSO is strongly associated with frailty in older adults according to the first study to define OSO using RFCSA measures.(c) 2022 Elsevier Inc. All rights reserved.