Multimodal integration and modulation of visual and somatosensory inputs on the corticospinal excitability

Yildiz F. G., TEMUÇİN Ç. M.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, cilt.53, sa.3, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.neucli.2022.102842
  • Dergi Adı: NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, MEDLINE
  • Anahtar Kelimeler: Visual cortex, Transcranial magnetic stimulation, Multimodal integration, Short latency afferent inhibition, Goggle LED
  • Hacettepe Üniversitesi Adresli: Evet

Özet

Objective: Corticospinal excitability may be affected by various sensory inputs under physiologi-cal conditions. In this study, we aimed to investigate the corticospinal excitability by using multi -modal conditioning paradigms of combined somatosensory electrical and visual stimulation to understand the sensory-motor integration.Methods: We examined motor evoked potentials (MEP) obtained by using transcranial magnetic stimulation (TMS) that were conditioned by using a single goggle-light-emitting diode (LED) stimulation, peripheral nerve electrical stimulation (short latency afferent inhibition protocol), or a combination of both (goggle-LED+electrical stimulation) at different interstimulus intervals (ISIs) in 14 healthy volunteers.Results: We found MEP inhibition at ISIs of 50-60 ms using the conditioned goggle-LED stimula-tion. The combined goggle-LED stimulation at a 60 ms ISI resulted in an additional inhibition to the electrical stimulation.Conclusions: Visual inputs cause significant modulatory effects on the corticospinal excitability. Combined visual and somatosensory stimuli integrate probably via different neural circuits and/ or interneuron populations. To our knowledge, multimodal integration of visual and somatosen-sory inputs by using TMS-short latency inhibition protocol have been evaluated via electrophysio-logical methods for the first time in this study.(c) 2022 Elsevier Masson SAS. All rights reserved.