Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?

İNKAYA, AHMET; Demir, Nazlim; Kolgelier, Servet; Sumer, Sua; Demir, Lutfi; Ural, Onur; PEHLIVAN, Fatma; Aslan, Mahmure; Arpaci, Abdullah

doi:10.1097/md.0000000000007547

Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?

İNKAYA A. Ç., Demir N. A., Kolgelier S., Sumer S., Demir L. S., Ural O., ...More

MEDICINE, vol.96, no.36, 2017 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 96 Issue: 36
Publication Date: 2017
Doi Number: 10.1097/md.0000000000007547
Journal Name: MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: alarmin molecules, chronic hepatitis B, high-mobility group box 1, liver fibrosis, STELLATE CELLS, VIRUS INFECTION, PROTEIN, FAILURE, ALARMINS, MARKER, INJURY
Hacettepe University Affiliated: Yes

Abstract

Background: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. We aimed to evaluate the association between serum levels of HMGB1 and liver fibrosis.