The role of CD14 gene promoter polymorphism in tuberculosis susceptibility


Ayaslioglu E., Kalpaklioglu F., Kavut A. B. , ERTÜRK A., ÇAPAN N., BİRBEN E.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, vol.46, no.3, pp.158-163, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jmii.2012.05.008
  • Title of Journal : JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
  • Page Numbers: pp.158-163
  • Keywords: CD14, polymorphism, soluble CD14, tuberculosis, CIRCULATING SOLUBLE CD14, PULMONARY TUBERCULOSIS, SERUM CONCENTRATIONS, INNATE IMMUNITY, SEPTIC SHOCK, INFECTION, DISEASE, SEPSIS, BRUCELLOSIS, ELEVATION

Abstract

Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population.