The role of CD14 gene promoter polymorphism in tuberculosis susceptibility

Ayaslioglu E., Kalpaklioglu F., Kavut A. B., ERTÜRK A., ÇAPAN N., BİRBEN E.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, vol.46, no.3, pp.158-163, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.jmii.2012.05.008
  • Journal Name: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.158-163
  • Keywords: CD14, polymorphism, soluble CD14, tuberculosis, CIRCULATING SOLUBLE CD14, PULMONARY TUBERCULOSIS, SERUM CONCENTRATIONS, INNATE IMMUNITY, SEPTIC SHOCK, INFECTION, DISEASE, SEPSIS, BRUCELLOSIS, ELEVATION
  • Hacettepe University Affiliated: Yes

Abstract

Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population.