The role of CD14 gene promoter polymorphism in tuberculosis susceptibility
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, cilt.46, sa.3, ss.158-163, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 3
- Basım Tarihi: 2013
- Doi Numarası: 10.1016/j.jmii.2012.05.008
- Dergi Adı: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.158-163
- Anahtar Kelimeler: CD14, polymorphism, soluble CD14, tuberculosis, CIRCULATING SOLUBLE CD14, PULMONARY TUBERCULOSIS, SERUM CONCENTRATIONS, INNATE IMMUNITY, SEPTIC SHOCK, INFECTION, DISEASE, SEPSIS, BRUCELLOSIS, ELEVATION
- Hacettepe Üniversitesi Adresli: Evet
Özet
Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population.