The Prognostic Significance of Prognostic Nutritional Index in Diffuse Large B Cell Lymphoma Patients

Aras M. R., Yilmaz F., Tiglioglu M., Saglam B., Yuzgenc B., Afacan Ozturk H. B., ...More

UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi, vol.33, no.1, pp.8-13, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.4999/uhod.236929
  • Journal Name: UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.8-13
  • Keywords: Diffuse large B cell lymphoma, Prognostic nutritional index, Albumin, Lymphocyte, Survival
  • Hacettepe University Affiliated: Yes

Abstract

The aim of the study was to determine the prognositc value of baseline prognostic nutritional index (PNI) in diffuse large B cell lymphoma (DLBCL) patitens. A retrospective analysis was made of patients diagnosed with diffuse large B cell lymphoma in our department between January 2012-February 2022. Patiens treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and predniso-lone were included the study. A receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of PNI. The prognostic role of PNI and survival outcomes were evaluated. One hundred and one patients with a median age of 66 [20-86] were included the study. The cut-off value of PNI was 48.8. Patients divided into two groups according to the PNI cut-off value. Com-pared to the PNI-low group (PNI ≤ 48.8), the PNI-high group (PNI > 48.8) had a significantly better overall survival and progression-free survival (p< 0.030 and p< 0.11, respectively). PNI can be used as a simple and useful predictor of prognosis in DLBCL patients.